COMPARISON OF THREE BENZODIAZEPINES FOR ORAL PREMEDICATION IN MINOR GYNAECOLOGICAL SURGERY

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Abstract
Diazepam 10 and 20 mg, lorazepam 2.5 and 5.0 mg, flunitrazepam 1 and 2 mg, and a placebo, were compared in a randomized double-blind controlled trial pa oral premedication for 210 patients undergoing minor gymecological surgery. Flunitrazepam 1 mg and lorazepam 2.5 mg were supaior to placebo (P<0.001 and P<0.05 respectively) in relieving patient anxiety whm asseased by a trained observer 60 min after premedication. Flunitrazepam 1 mg also produced more drowsfness (P<0.01) than the placebo. Camparisom of other low-dose benzodiazepine groups with the placebo, and of the large dose with the small dose of each drug revealed no significant changes in anxiolysis or drowsiness. Dizziness and prolonged drowsiness were not apparent with low-dose flunitrazepam. The data suggests that flunitrazepam 1 mg offers advantages over placebo, diazepam 10 mg and lorazepam 2.5 mg for routine oral pranedication in minor gynaecological surgery.

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