Thyroid Function in Patients with Aspermiogenesis and Testicular Tubular Sclerosis

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Abstract
IN 1942 Klinefelter et al.1 described a syndrome of micro-orchidism, azoospermia, hyalinization of seminiferous tubules, elevated urinary follicle-stimulating hormone (FSH) and gynecomastia. Since then it has become apparent from numerous reports that Klinefelter's syndrome may be variously manifested but at least consists of micro-orchidism, oligospermia, hyalinization of seminiferous tubules2 (even though occasional areas of spermatogenesis may be seen3 4 5 6 7), an apparent increase in Leydig cells and an elevated FSH level.1 , 8 , 9 There may or may not be gynecomastia,2 , 7 the body habitus may range from the eunuchoid to the male type,5 6 7 , 10 the I.Q. may be normal to subnormal,10 11 12 13 14 15 and the chromosomal pattern . . .