Specific binding ofadaic acid, a new tumor promoter in mouse skin
Open Access
- 3 July 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 250 (2) , 615-618
- https://doi.org/10.1016/0014-5793(89)80807-5
Abstract
The tumor promoteradaic acid binds specifically to a particulate as well as a cytosolic fraction of various mouse tissues, e.g., skin, brain, lung and colon. The K D value was 21.7 nM for receptors in the particulate fraction and 1.0 nM for those in the cytosolic fraction of mouse skin. The specific binding of [3H]okadaic acid to the particulate fraction of mouse skin was inhibited dose‐dependently byadaic acid, but notaidaic acid tetramethyl ether, an inactive compound, or by other tumor promoters, such as 12‐O‐tetradecanoylphorbol‐13‐acetate and teleocidin. The results suggest a new pathway of tumor promotion mediated through theadaic acid receptor(s).Keywords
This publication has 16 references indexed in Scilit:
- Apparent “activation” of protein kinases by okadaic acid class tumor promotersBiochemical and Biophysical Research Communications, 1989
- Diarrhetic Shellfish Toxin, Dinophysistoxin‐1, Is a Potent Tumor Promoter on Mouse SkinJapanese Journal of Cancer Research, 1988
- Production of antibodies and development of a radioimmunoassay for okadaic acidToxicon, 1988
- Induction of ornithine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acid.Proceedings of the Japan Academy, Series B, 1987
- Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesisCarcinogenesis: Integrative Cancer Research, 1986
- Okadaic acid, a cytotoxic polyether from two marine sponges of the genus HalichondriaJournal of the American Chemical Society, 1981
- Direct measurment of specific binding of highly lipophilic phorbol diester to mouse epidermal membranes using cold acetoneBiochemical and Biophysical Research Communications, 1981
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949