Scatter Factor Regulates Vascular Endothelial Cell Motility
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Cancer Investigation
- Vol. 8 (6) , 647-650
- https://doi.org/10.3109/07357909009018936
Abstract
Scatter factors (SFs) are mesenchymal cellderived cytokines which stimulate epithelial motility. SF purified from ras-transformed 3T3 cell supernatants markedly stimulated vascular endothelial cell migration at < 100 pM. Preliminary studies suggest endothelial lines with cobblestone (epithelioid) morphology respond to SF, while those lines with elongated cells do not respond. SFs may play roles in development and tissue repair.Keywords
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