Effects of 6-Mercaptopurine on Respiration, Anaerobic Glycolysis and Succino-Dehydrogenase Activity in Normal and Tumor Tissues.
- 1 August 1956
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 92 (4) , 758-762
- https://doi.org/10.3181/00379727-92-22605
Abstract
Chronic treatment with tolerated doses of 6-mercaptopurine causes a reduction of 50% or more in the respiratory and anaerobic glycolysis of sarcoma 180 while it does not impair the metabolic func tions in liver and kidney. Succinic dehydrogenase activity of sarcoma 180 is also impaired by treatment with 6-mercaptopurine, but this ef fect does not seem to be great enough to account fully for the observed reduction in respiration.Keywords
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