Expression of Adhesion Molecules in Cultured Human Nasal Mucosal Microvascular Endothelial Cells Activated by Interleukin–1â or Tumor Necrosis Factor–·: Effects of Dexamethasone

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Abstract
Adhesion molecules of microvascular endothelial cells play a key role in the inflammatory processes involved in nonallergic sinusitis. We investigated the cytokine–regulated expression of intercellular adhesion molecule–1 (ICAM–1), E–selectin and vascular cell adhesion molecule–1 (VCAM–1), and the effect of dexamethasone on these expressions in cultured human nasal microvascular endothelial cells (HNMEC). ICAM–1 was enhanced, and E–selectin and VCAM–1 were induced in a dose–dependent fashion following stimulation with IL–1β or TNF–α. HNMEC differed from human umbilical vein endothelila cells in that (1) maximal upregulation of ICAM–1 expression induced by IL–1β or TNF–α required more time (2) TNF–α was more potent than IL–1β in VCAM–1 expression, and (3) dexamethasone inhibited the upregulation of E–selectin expression alone. These findings contribute to a better understanding of the characteristic features of leukocyte infiltration into inflamed tissue and the effect of glucocorticoid in nonallergic chronic sinusitis.