Translocation t(1; 19) in Acute Lymphoblastic Leukemia Patients with Cytological Presentation Simulating L3–ALL (Burkitt-Like)

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Abstract
The t(1;19) in B-lineage ALL is classically associated with a FAB LI/L2 phenotype and the expression of cIg. Recent reports have demonstrated immuno-phenotypic and molecular heterogeneity among cases demonstrating apparently identical karyotypic abnormalities. We report 5 cases of t(1; 19) with cytological features resembling an L3 (Burkitt-like) phenotype, suggesting that accurate assessment of these cases requires detailed correlation of cytological, immunological and molecular characteristics.