SEROTONIN IS REDUCED IN THE FRONTAL CORTEX OF SARDINIAN ETHANOL-PREFERRING RATS
Open Access
- 1 May 1998
- journal article
- research article
- Published by Oxford University Press (OUP) in Alcohol and Alcoholism
- Vol. 33 (3) , 226-229
- https://doi.org/10.1093/oxfordjournals.alcalc.a008386
Abstract
Ethanol-naive Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats were tested to evaluate the levels of serotonin (5-HT) and 5-hydroxyindol-3-yl-acetic acid (5-HIAA) in the frontal cortex, hypothalamus, and nucleus accumbens, and the levels of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the hypothalamus and nucleus accumbens. Compared with the sNP line, the sP rats had lower 5-HT and 5-HIAA concentrations in the frontal cortex, whereas no differences were found in the other brain areas tested, neither for neurotransmitters nor their metabolites. As the decreased 5-HT function is a feature shared by different alcohol-preferring strains, it could be linked to the genetic predisposition to voluntary ethanol consumption.Keywords
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