Sites of synthesis of plasma proteins in the foetal rat

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Abstract
The fetal rat of 16 or more days incorporates 14C-labelled amino acids into all the demonstrable plasma protein fractions in vivo. Slices of fetal rat liver incubated in vitro incorporate 14C-labelled amino acids into the main plasma protein fractions, including the fetal-specific "post-albumin". Slices of placenta are unable to incorporate 14C- labelled amino acids into plasma proteins in vitro. Liver slices from maternal rats incubated in vitro incorporate 14C-labelled amino acids into plasma proteins. The presence of post-albumin cannot be demonstrated after incubation. Liver slices from fetal rats, but not from adult rats, contain demonstrable amounts of hemoglobin into which 14C-labelled amino acids are incorporated.