Effect of Dietary Fat on Fatty Acid Composition of Mouse and Rat Mammary Adenocarcinomas

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Abstract
The fatty acid composition of 4 mammary adenocarcinomas carried by C3H and BALB/c mice and one carried by the Fischer rat fed different dietary fats is presented. In general, the neoplastic tissue fatty acid profiles reflected those of the dietary fat in that those tumors taken from animals fed polyunsaturated fats contained greater amounts of linoleate and arachidonate than those fed a saturated fat or a fat-free diet. Mammary tumor fatty acid composition changed almost as rapidly as it did in host liver in response to alterations in the type of dietary fat. The rate of tumor growth could not be correlated with the levels of 20:4 found in all murine mammary adenocarcinomas. Although low levels (0.1%) of pure 18:0 and 18:2 had little effect on the fatty acid composition of tumor lipids, this level of 18:2 was sufficient to enhance tumor growth in BALB/c mice. The administration of 5,8,11,14-eicosatetraynoic acid (TYA) to BALB/c mice retarded the increased growth of transplanted mammary tumors in mice fed diets which contained pure cis-9-cis-12-octadecadienoic acid. This effect of TYA confirms previous observations made with mammary adenocarcinomas in C3H mice in that 18:2 levels increased while 20:4 and 20:3 .omega.9 levels decreased.

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