EXHAUSTION PHENOMENON IN THYROID PRODUCED BY PITUITARY TREATMENT: HISTOLOGICAL STUDY OF RABBIT’S THYROID UNDER VARYING DEGREES OF ANTERIOR PITUITARY THERAPY

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Abstract
Fifty rabbits, aged 15-20 weeks, received, in groups, saline emulsions or sterile acid and alkaline extracts of anterior pituitary of beef, or control injections. The control injections were ineffective. The animals treated with pituitary substance (0.1-1.0 gm. or equivalent of extracts) for 2-7 days showed thyroid hyperplasia. Animals treated for 7-12 days showed early regressive and involutional changes following hyperplasia. Animals treated for 12-28 days showed increased involution and atrophy of epithelium and marked colloid storage.

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