Plasma High Density Lipoprotein Cholesterol in Thyroid Disease*

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Abstract
The plasma levels of high density lipoprotein cholesterol (HDL-C) were reduced in 16 hyperthyroid female patients compared to 37 euthyroid women (33.5 ± 8 vs. 51.5 ± 13 mg⁄dl (mean ± SD); P < 0.001), When 5 patients were restudied after restoration of the euthyroid state, plasma HDL-C increased from 29 ± 5 to 43 ± 11.5 mg⁄dl (P < 0.05). In addition, in 22 hypothyroid women, HDL-C levels were also diminished com-pared to the euthyroid group (43.4 ± 15.5 vs. 51.5 ± 13 mg⁄dl; P < 0.05). Nine patients were restudiedafter L-T4 replacement therapy; their levels of HDL-Cincreased but not toa statistically significant degree. The daily administration of 0.3 mg (L-T)4to eight normal male volunteers for 1 month did not significantly affect HDL-C levels. (JClin Endocrinol Metab49: 726, 1979)