Mthfd1 Is an Essential Gene in Mice and Alters Biomarkers of Impaired One-carbon Metabolism
Open Access
- 1 January 2009
- journal article
- Published by Elsevier
- Vol. 284 (3) , 1533-1539
- https://doi.org/10.1074/jbc.m808281200
Abstract
No abstract availableKeywords
This publication has 35 references indexed in Scilit:
- Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in MicePublished by Elsevier ,2008
- Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductaseMolecular Genetics and Metabolism, 2007
- Small ubiquitin-like modifier-1 (SUMO-1) modification of thymidylate synthase and dihydrofolate reductasecclm, 2007
- Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish populationEuropean Journal of Human Genetics, 2006
- MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentaeAmerican Journal of Medical Genetics Part A, 2005
- Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: physiological impact in acidosis and alkalosisAmerican Journal of Physiology-Cell Physiology, 2004
- Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donorAmerican Journal of Physiology-Endocrinology and Metabolism, 2004
- Cytoplasmic Serine Hydroxymethyltransferase Mediates Competition between Folate-dependent Deoxyribonucleotide andS-Adenosylmethionine BiosynthesesJournal of Biological Chemistry, 2002
- NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase in transformed cells is a mitochondrial enzymeBiochemical and Biophysical Research Communications, 1988
- Kinetic isotope effects on the oxidation of reduced nicotinamide adenine dinucleotide phosphate by the flavoprotein methylenetetrahydrofolate reductaseBiochemistry, 1984