COLORECTAL-CANCER AND SCHISTOSOMIASIS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 1  (8227) , 971-973
Abstract
The risk of colorectal cancer has increased in patients with long-standing schistosomal colitis. A retrospective review of clinical data and surgical specimens from 60 patients with schistosomal granulomatous disease of the large intestine but without carcinoma demonstrated that 36 of them had mild to severe grades of colonic epithelial dysplasia. This was focal or diffuse in distribution and occurred in flat mucosa, in pseudopolyps or in regenerating epithelium at the edges of ulcers. These dysplastic changes are regarded as the pathological basis for the malignant potential of schistosomal colitis and they resemble the changes found in long-standing chronic ulcerative colitis.