Pancreatic Amylin Content in Human Diabetic Subjects and Its Relation to Diabetes

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Abstract
To evaluate the role of pancreatic amylin in the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM), we determined the pancreatic amylin (IRA) and insulin (IRI) contents of pancreata obtained at autopsy from diabetics and nondiabetics. IRA was extracted from the tail of the pancreas using formic acid and assayed with a human amylin kit. Following gel filtration of amylin on a Sephadex G-50 column, it was eluted in a similar fraction to insulin. The pancreatic IRA content was significantly higher (p 10 μg/g) were all elderly men with a long duration of diabetes. Thus, although the pancreatic amylin content was increased in NIDDM, no significant relationship to the clinical features of the disease was found.

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