On the attribution and additivity of binding energies

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Abstract
It can be useful to describe the Gibbs free energy changes for the binding to a protein of a molecule, A—B, and of its component parts, A and B, in terms of the “intrinsic binding energies” of A and B, Δ G A i and Δ G B i , and a “connection Gibbs energy,” Δ G s that is derived largely from changes in translational and rotational entropy. This empirical approach avoids the difficult or insoluble problem of interpreting observed ΔH and T Δ S values for aqueous solutions. The Δ G i and Δ G s terms can be large for binding to enzymes and other proteins.