Influence of different background and left-ventricular assignments on the ejection fraction in equilibrium radionuclide angiography.

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Abstract
Patients (76) were studied with 1 wk of contrast ventriculography to assess the influence of differing background assignments on ejection fractions derived from gated equilibrium radionuclide angiograms. Fixed and variable left-ventricular regions of interest and 5 different backgrounds were used. Inter- and intra-observer variability were determined and 15 patients underwent a 2nd study 2 weeks later. Variable left-ventricular regions of interest produced higher ejection fractions than fixed ones. A computer-assigned background or a ring drawn manually around the left ventricle correlated best with contrast ventriculography, giving greater serial and inter- and intra-observer variability. Automated background assignments reduced variability and increased reproducibility, though they were not always associated with the best correlation with contrast ventriculography. A variety of left-ventricular and background regions of interest gives excellent reproducibility and accuracy.

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