The Capsule of Bacillus anthracis Behaves as a Thymus-Independent Type 2 Antigen
Open Access
- 1 September 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (9) , 5460-5463
- https://doi.org/10.1128/iai.72.9.5460-5463.2004
Abstract
Bacillus anthracis elaborates a homopolymeric capsule composed of γ-d-glutamic acid residues. Mice were immunized with formalin-fixed encapsulated B. anthracis bacilli, and the serum antibody response to a γ-d-glutamyl capsular epitope was measured. Antiglutamyl antibodies were elicited in athymic BALB/c Nu/Nu, BALB/c Nu/+, and CBA/J mice but not in CBA/N xid mice. These response patterns define the capsule of B. anthracis as a thymus-independent type 2 antigen.Keywords
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