The Absorption Characteristics of Paracetamol Tablets in Man
- 1 September 1963
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 15 (1) , 445-453
- https://doi.org/10.1111/j.2042-7158.1963.tb12812.x
Abstract
Paracetamol tablets from different sources showed widely differing absorption patterns in man. As judged by a blood concentration at 45 min. of less than 10 μg./ml. whole blood, low absorption was usually found in 25 per cent of subjects. This may be reduced to less than 10 per cent by a new paracetamol/sorbitol tablet. This combination produced higher average blood levels at 45 min. than crushed tablets of paracetamol. There appears to be a relation between the absorption of the drug and both age and weight; this variation can be reduced by paracetamol/sorbitol.Keywords
This publication has 9 references indexed in Scilit:
- The Absorption Characteristics of Paracetamol Tablets in ManJournal of Pharmacy and Pharmacology, 1963
- Determination of Blood and Other Tissue Concentrations of Paracetamol in Dog and ManJournal of Pharmacy and Pharmacology, 1963
- Enhancement of Serum Vitamin B12byᴅ-SorbitolThe American Journal of Clinical Nutrition, 1959
- Effect of ᴅ-Sorbitol on Absorption of Vitamin B12 by Human Subjects Able To Produce Intrinsic FactorThe American Journal of Clinical Nutrition, 1959
- A Comparison of Human Serum Levels of Acetylsalicylic Acid, Salicylamide, and N-Acetyl-p-Aminophenol Following Oral Administration**Department of Pharmacology, Research Division, Mead Johnson & Company, Evansville, IndJournal of the American Pharmaceutical Association (Scientific ed.), 1958
- N-ACETYL-P-AMINOPHENOL (TYLENOL ELIXIR) AS A PEDIATRIC ANTIPYRETIC-ANALGESICJAMA, 1956
- Plasma Levels After the Oral Administration of Acetylsalicylic Acid and N-Acetyl-P-Aminophenol in Different Forms to Human Subjects*Journal of the American Pharmaceutical Association (Scientific ed.), 1955
- THE FATE OF ACETOPHENETIDIN (PHENACETIN) IN MAN AND METHODS FOR THE ESTIMATION OF ACETOPHENETIDIN AND ITS METABOLITES IN BIOLOGICAL MATERIAL1949
- THE METABOLIC FATE OF ACETANILID AND OTHER ANILINE DERIVATIVES .2. MAJOR METABOLITES OF ACETANILID APPEARING IN THE BLOOD1947