How to Resolve an Ethical Dilemma Concerning Randomized Clinical Trials

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Abstract
An apparent ethical dilemma arises when physicians consider enrolling their patients in randomized clinical trials. Suppose that a randomized clinical trial comparing two treatments is in progress, and a physician has an opinion about which treatment is better. The physician has a duty to promote the patient's best medical interests and therefore seems to be obliged to advise the patient to receive the treatment that the physician prefers. This duty creates a barrier to the enrollment of patients in randomized clinical trials.110 Two strategies are often used to resolve the dilemma in favor of enrolling patients in clinical trials. . . .

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