Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
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Open Access
- 1 April 2003
- journal article
- review article
- Published by Oxford University Press (OUP)
- Vol. 58 (1) , 32-45
- https://doi.org/10.1016/s0008-6363(02)00846-5
Abstract
Objective: To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for predicting risk of torKeywords
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