Mureidomycins A-D, novel peptidylnucleoside antibiotics with spheroplast forming activity. I. Taxonomy, fermentation, isolation and physico-chemical properties.

1 January 1989

journal article
research article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 42 (5) , 662-666
https://doi.org/10.7164/antibiotics.42.662

Abstract

A strain of actinomycetes identified as Streptomyces flavidovirens produced new antibiotics, mureidomycins (MRD''s) A .apprx. D, specifically active against Pseudomonas aeruginosa. They were isolated from the culture filtrate by successive column chromatographies such as Amberlite XAD-2 and CG-50, Whatman DE-52 and Toyopearl HW-40. They were amphoteric white powders and soluble in methanol and water. Their molecular weights and molecular formulae in parentheses were 840 (C38H48N8O12S), 842 (C38H50N8O12S), 897 (C40H51N9O13S) and 899 (C40H53N9O13S), respectively. m-Tyrosine and two unknown substances were detected by amino acid analyses as their common constituents. MRD''s A and C contained uracil but MRD''s B and D dihydrouracil instead of uracil.

This publication has 0 references indexed in Scilit: