Inhibition of Neutrophil Chemotactic Factor Production in Comedonal Bacteria by Subminimal Inhibitory Concentrations of Erythromycin
- 1 January 1992
- journal article
- pharmacology and-treatment
- Published by S. Karger AG in Dermatology
- Vol. 185 (1) , 41-43
- https://doi.org/10.1159/000247401
Abstract
The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains, Propionibacterium granulosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.Keywords
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