An Improved Reaction of tris(Methylthio) methane with Epoxides: Application to the Efficient Synthesis of β-Hydroxy Esters
- 1 March 1993
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 23 (6) , 811-815
- https://doi.org/10.1080/00397919308009842
Abstract
Tris(methylthio) methyllithium reacts efficiently with epoxides in THF:HMPA (5:1) at low temperature to give β-hydroxy orthotrithiocarboxylates which are converted to β-hydroxy esters in high yield.Keywords
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