Enzymatic cleavage and formation of cyanohydrins: a reaction of biological and synthetic relevance
- 1 January 1997
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 20,p. 1933-1940
- https://doi.org/10.1039/a700907k
Abstract
Hydroxynitrile lyases (Hnls) catalyse enantioselectively both the cleavage and formation of cyanohydrins. Besides the well known (R)-selective enzyme from almonds, (S)-Hnls have recently become available in larger quantities by cloning and over-expression. The first three-dimensional structure of a Hnl has been established for the enzyme from Hevea brasiliensis. These results are the basis for a still broader application of Hnls for biocatalytic asymmetric syntheses on a preparative scale.Keywords
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