Mechanism of Changes in Brain Norepinephrine Metabolism after Ovariectomy

1 January 1970

journal article
Published by S. Karger AG in Neuroendocrinology

Vol. 6 (5-6) , 265-273
https://doi.org/10.1159/000121947

Abstract

Oophorectomy accelerates the turnover of ³H-norepinephrine (³H-NE) in rat brain, but does not decrease endogenous brain norepinephrine content. If ovariectomized rats are treated with a given dose of (α-MPT), an inhibitor of norepinephrine synthesis, brain norepinephrine α-Methyl para-tyrosine levels do not fall to the same extent as in unoperated animals given the same dose of α-MPT, even though the turnover of brain ³H-NE continues to be accelerated. These data indicate that ovariectomy increases brain norepinephrine synthesis, and also decreases the sensitivity of rats to inhibitors of norepinephrine synthesis such as α-MPT. Ovariectomy or treatment with follicle-stimulating hormone (FSH) also increases the accumulation of ³H-catechols (predominantly ³H-NE) in rat brain, following the intraperitoneal administration of ³H-tyrosine.

Keywords

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