INVIVO DISTRIBUTION OF TC-99M(SN)PYRIDOXYLIDENEISOLEUCINE - EFFECTS OF STORAGE AND LABELING CONDITIONS - CONCISE COMMUNICATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 20  (11) , 1189-1193
Abstract
Various conditions for the storage of the stannous pyridoxylideneisoleucine (Sn-P.isoL) kit reagent and for the preparation of 99mTc (Sn)P. isoL were evaluated experimentally using rats. The frozen (-30.degree. C) and freeze-dried state were suitable for storage of the kit reagent. For the labeling procedure at least 40 min incubation time (Sn-P.isoL + 99mTc04-) was necessary at room temperature. The same superior results could be obtained quickly by heating the mixed solution for 2 min in a boiling-water bath. The pertechnetate could be added in a volume up to 4 times that of the kit reagent. Mo(VI) and/or AI(III) in the pertechnetate solution did not interfere with the formation of Tc-99m(Sn)P.isoL up to the highest tested concentration of 40 .mu.g/ml each.

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