The Role of Cardiopulmonary Sympathetic Afferents in Blood Volume Homoeostasis in the Non-Human Primate

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Abstract
Four Macaca fascicularis monkeys were bilaterally sympathectomized by removing the thoracic sympathetic chain from the middle cervical ganglion to the T-6 sympathetic ganglion. This was done chronically, allowing adequate recovery time. While under light pentobarbital anesthesia, the animals were then subjected to blood volume expansions with isotonic, isooncotic dextran or to head-out immersions. Seven immersions and 7 volume expansions were carried out. With immersion, there were significant increases in blood pressure, central venous pressure, urine flow, Na excretion, K excretion, glomerular filtration rate, percentage of filtered Na excreted and free H2O clearance. Although blood pressure and central venous pressure initially increased during the 1st immersion period, heart rate continued to increase with the immersion, while blood pressure and central venous pressure remained constant. Volume expansion caused an increase in central venous pressure, urine flow, Na and K excretion, osmolar clearance, free H2O clearance, percentage of filtered Na excreted and glomerular filtration rate. Since these results with both the immersions and volume expansions were not qualitatively different from those observed in control animals, cardiopulmonary sympathetic afferents apparently are not necessary for the renal response to head-out immersion of blood volume expansion in the non-human primate.

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