MUTAGENICITY OF ACLACINOMYCIN-A AND DAUNOMYCIN DERIVATIVES

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (6) , 1782-1784
Abstract
An antitumor antibiotic, aclacinomycin A, was nonmutagenic in a Salmonella test, but its derivative, N-demethylaclacinomycin A, was mutagenic. 1-Deoxypyromycin, a hydrolysis product of aclacinomycin A, was nonmutagenic, but N-demethyl-1-deoxypyrromycin was mutagenic. Daunomycin was highly mutagenic, but N-methyldaunomycin showed only weak mutagenicity, and N-dimethyldaunomycin was nonmutagenic. The aglycones of aclacinomycin A and daunomycin were not mutagenic. The amino moiety of anthracycline glycosides is concluded to be essential for mutagenesis.