Amoebicidal activity of the antifungal antibiotic sinefungin against Entamoeba histolytica

Abstract

The antifungal antibiotic sinefungin, a potent inhibitor of methyl transferases and a potential inhibitor of polyamine biosynthesis, exhibited marked cytolytic activity against Entamoeba histolytica in vitro with respect to all the amoeba strains tested. Strains of high and low virulence displayed equal sensitivity to the antibiotic. Minimal Amoebicidal Concentration was 5 to 10 micrograms/ml.

Keywords

This publication has 17 references indexed in Scilit:

The effect of adenosine analogues on the in vitro growth of Trypanosoma cruzi
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1982
Effects of S-adenosylhomocysteine analogs on vaccinia viral mRNA synthesis and methylation
Biochemistry, 1982
Content, Synthesis, and Function of Polyamines in Trypanosomatids: Relationship to Chemotherapy1^,2
The Journal of Protozoology, 1981
Inhibitory activity of sinefungin and siba (5′‐deoxy‐5′‐S‐isobutylthio‐adenosine) on the growth of promastigotes and amastigotes of different species of leishmania
FEBS Letters, 1980
Studies of inhibition of rat spermidine synthase and spermine synthase
Biochemical Journal, 1980
Sinefungin, a potent inhibitor of S-adenosylmethionine: Protein O-methyltransferase
Biochemical and Biophysical Research Communications, 1979
Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.
Journal of Biological Chemistry, 1978
Inhibition of methyltransferases by some new analogs of S-adenosylhomocysteine
Biochemical Pharmacology, 1978
A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC
The Journal of Antibiotics, 1973
A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC
The Journal of Antibiotics, 1973