Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease–Like Pathology and Cognitive Decline
- 24 June 2011
- journal article
- research article
- Published by Elsevier in The American Journal of Pathology
- Vol. 179 (2) , 980-991
- https://doi.org/10.1016/j.ajpath.2011.04.041
Abstract
No abstract availableKeywords
Funding Information
- National Institute on Aging (R01AG20335, AG00538, K99AR054695)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AG20335, AG00538, K99AR054695)
- National Institutes of Health (R01AG20335, AG00538, K99AR054695)
This publication has 56 references indexed in Scilit:
- CREB is a regulatory target for the protein kinase Akt/PKB in the differentiation of pancreatic ductal cells into islet β-cells mediated by hepatocyte growth factorBiochemical and Biophysical Research Communications, 2011
- Deletion of M1Muscarinic Acetylcholine Receptors Increases Amyloid PathologyIn VitroandIn VivoJournal of Neuroscience, 2010
- Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampusProceedings of the National Academy of Sciences, 2010
- Role of the Macrophage Inflammatory Protein-1α/CC Chemokine Receptor 5 Signaling Pathway in the Neuroinflammatory Response and Cognitive Deficits Induced by β-Amyloid PeptideThe American Journal of Pathology, 2009
- Novel Selective Allosteric Activator of the M1Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in RatsJournal of Neuroscience, 2008
- Lithium Reduces Tau Phosphorylation but Not Aβ or Working Memory Deficits in a Transgenic Model with Both Plaques and TanglesThe American Journal of Pathology, 2007
- Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant miceNature Neuroscience, 2002
- Glycogen synthase kinase-3β phosphorylates tau protein at multiple sites in intact cellsNeuroscience Letters, 1995
- Conventional protein kinase C (PKC)‐α and novel PKCε, but not ‐δ, increase the secretion of an N‐terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblastsFEBS Letters, 1995
- Differential alterations in muscarinic receptor subtypes in Alzheimer's disease: Implications for cholinergic-based therapiesLife Sciences, 1995