Intestinal Absorption of Cadmium and Inorganic Mercury in the Rat: No Major Involvement of Metallothionein
- 1 January 1987
- book chapter
- Published by Springer Nature
- Vol. 52, 639-646
- https://doi.org/10.1007/978-3-0348-6784-9_68
Abstract
The intestinal absorption of cadmium and inorganic mercury was studied in adult rats, administered the metal salts intragastrically or parenterally in repeated or single doses. The intestines contained only small proportion of the body burden; no major change was found in the intestinal level of metallothionein, copper and zinc. Therefore, no major role can be ascribed to intestinal metallothionein in limiting absorption of high oral doses of cadmium and mercury.Keywords
This publication has 14 references indexed in Scilit:
- Effects of cadmium and zinc on tissue levels of metallothionein.Environmental Health Perspectives, 1984
- Age and intestinal retention of mercury and cadmium in ratsEnvironmental Research, 1983
- Isolation and properties of cadmium‐binding protein induced in rat small intestine by oral administration of cadmiumJournal of Toxicology and Environmental Health, 1982
- Gastrointestinal absorption and organ distribution of oral cadmium chloride and cadmium‐metallothionein in miceJournal of Toxicology and Environmental Health, 1978
- The levels of metallothionein-like proteins in animal tissuesCellular and Molecular Life Sciences, 1977
- Toxicity and distribution of cadmium administered to rats at sublethal dosesToxicology and Applied Pharmacology, 1977
- Isolation of an intestinal metallothionein induced by parenteral zincBiochemical and Biophysical Research Communications, 1977
- Mammalian zinc homeostasis: Requirement for RNA and metallothionein synthesisBiochemical and Biophysical Research Communications, 1975
- Binding of cadmium and mercury by metallothionein in the kidneys and liver of rats following repeated administrationArchives of Toxicology, 1974
- Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: Induction of metallothionein by mercury and cadmiumToxicology and Applied Pharmacology, 1974