Coagulopathy and Hemorrhage Associated With Cefoperazone Therapy in a Patient With Renal Failure

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Abstract
We have reported life-threatening gastrointestinal hemorrhage with hypoprothrombinemia in a patient treated with cefoperazone for a urinary tract infection. The coagulation abnormality was rapidly corrected with administration of vitamin K and discontinuation of the antibiotic. This complication of cefoperazone therapy is not widely recognized and may be seen more frequently with increased use of the drug.

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