The Use of Surfactants to Enhance the Permeability of Peptides Through Caco-2 Cells by Inhibition of an Apically Polarized Efflux System
- 1 January 1996
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 13 (4) , 528-534
- https://doi.org/10.1023/a:1016033702220
Abstract
Purpose. It has recently been reported that the permeability of peptides across Caco-2 cells, an in vitromodel of the intestinal mucosa, was limited by an apically polarized efflux mechanism. Since...Keywords
This publication has 22 references indexed in Scilit:
- Solubilization of membranes by detergentsPublished by Elsevier ,2003
- Effects of nonionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance.1993
- Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulatorsJournal of Biological Chemistry, 1993
- BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTERAnnual Review of Biochemistry, 1993
- Reversal of multidrug resistance by surfactantsBritish Journal of Cancer, 1992
- The Influence of Peptide Structure on Transport Across Caco-2 Cells. II. Peptide Bond Modification Which Results in Improved PermeabilityPharmaceutical Research, 1992
- REVERSAL OF THE MULTIDRUG RESISTANCE PHENOTYPE WITH CREMOPHOR EL, A COMMON VEHICLE FOR WATER-INSOLUBLE VITAMINS AND DRUGS1990
- Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) CellsJournal of Pharmaceutical Sciences, 1990
- THE SOLVENTS CREMOPHOR-EL AND TWEEN-80 MODULATE DAUNORUBICIN RESISTANCE IN THE MULTIDRUG RESISTANT EHRLICH ASCITES TUMOR1990
- Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal MucosaPharmaceutical Research, 1990