MICC CYTOTOXIC EFFECTOR FUNCTION OF HUMAN LYMPHOCYTE-T SUB-POPULATIONS BEARING FC-RECEPTORS FOR IGG AND IGM

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 37  (3) , 558-561
Abstract
Purified subpopulations of human T [thymus-derived] lymphocytes bearing Fc-Ig[immunoglobulin]G and Fc-IgM recpetors were studied for their ability to mediate mitogen (PHA) induced cellular cytotoxicity (MICC) to chicken erythrocyte (CRBC) and DBA/[mouse] mastocytoma P815Y tumor cell targets. There were marked differences in the ability of the Fc-IgG receptor-bearing T cell (T.gamma.) and the Fc-IgM (T.mu.) to mediating MICC to CRBC and P815Y target cells. T.gamma. cells were very efficient killers of CRBC and T.mu. cells had no cytotoxic activity to CRBC. The T.gamma. and T.mu. subpopulations could mediate MICC to P815Y tumor cell targets.