Ability of base analogs to induce the SOS response: effect of a dam mutation and mismatch repair system
- 1 December 1985
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 201 (3) , 519-524
- https://doi.org/10.1007/bf00331349
Abstract
2-Aminopurine, 2-amino-N6-hydroxyadenine, 2-amino-N6-methoxyadenine and 2-amino-N6-methyl-N6-hydroxyadenine (but not N4-hydroxycytidine), strong mutagens of base analog type, may induce the SOS response in E. coli cells. This ability is greatly enhanced in dam3 mutants and abolished in dam3mutS, dam3mutH, and dam3mutL strains, thereby suggesting that the mismatch repair system is involved in the mechanism of induction.This publication has 40 references indexed in Scilit:
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