CLINICAL SIGNS, RADIOLOGY AND TISSUE LEAD DISTRIBUTION OF DOGS ADMINISTERED A MIXTURE OF LEAD CHLORIDE, LEAD BROMIDE AND LEAD SULPHATE

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Abstract
Dogs (8 mo. old) maintained on a high fat low Ca diet were administered a mixture of PbCl2, PbBr2 and PbSO4 for prolonged periods at 4 different dose levels. Dogs on high levels of Pb showed marked weight loss and gastrointestinal symptoms followed by death. Two dogs on low Pb levels developed neurological signs. Radiological investigations showed radiopaque particles in 27% of abdominal radiographs and Pb lines in the distal radius of 3 dogs. Highest tissue Pb levels were found in bones followed by liver and kidney, brain and spinal cord.

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