Oxotremorine Acts as a Partial Nicotinic Agonist on Cultured Chick Myotubes
- 13 March 2009
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 57 (5) , 317-321
- https://doi.org/10.1111/j.1600-0773.1985.tb00051.x
Abstract
Oxotremorine, a compound widely used as a muscarinic agonist, was found to inhibit binding of 125I-.alpha.-bungarotoxin to chick myotube nicotine acetylcholine receptors, IC50 = 79 .+-. 5 .mu.M. Oxotremorine also induced a d-tubocurarine sensitive influx of 86Rb in the myotubes (EC50 = 50 .+-. 15 .mu.M). Comparative ion-influx studies with carbachol suggested a partial agonist mode of action of oxotremorine.Keywords
This publication has 16 references indexed in Scilit:
- A comparison of the stimulant activities of oxotremorine analogues on the frog rectus abdominis and the guinea pig ileumEuropean Journal of Pharmacology, 1984
- High-affinity [3H]pirenzepine binding to putative M1 muscarinic sites in the neuroblastoma × glioma hybrid cell line (NG 108-15)Biochemical and Biophysical Research Communications, 1984
- Pharmacological properties of oxotremorine and its analogsLife Sciences, 1983
- Separate sites of low and high affinity for agonists on Torpedo californica acetylcholine receptorBiochemistry, 1983
- The Pharmacology of Nerve and Muscle in Tissue CulturePublished by Springer Nature ,1983
- Pre- and postsynaptic effects of muscarinic agonists in the guinea-pig ileumNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1980
- LIGAND BINDING TO MUSCARINIC RECEPTORS IN INTACT LONGITUDINAL MUSCLE STRIPS FROM GUINEA‐PIG INTESTINEBritish Journal of Pharmacology, 1977
- The action of acetylcholine and other drugs on the efflux of potassium and rubidium from smooth muscle of the guinea‐pig intestineBritish Journal of Pharmacology, 1968
- Oxotremorine at the neuromusculair junctionEuropean Journal of Pharmacology, 1967