The biochemistry of apoptosis
Top Cited Papers
- 1 October 2000
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 407 (6805) , 770-776
- https://doi.org/10.1038/35037710
Abstract
Apoptosis — the regulated destruction of a cell — is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.Keywords
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