Regulation of Klebsiella pneumoniae hut operons by oxygen

Abstract
The regulation of genes concerned with N metabolism by O2 in the facultative anaerobe K. pneumoniae was investigated. O2 was required for the expression of the hut operons; the effect of O2 on glutamine synthetase and urease was less pronounced than on the hut operons. Glutamine synthetase was transiently repressed during the transition from an aerobic to an anaerobic environment. Regulation of hut by O2 suppressed the effect of N limitation on the expression of these genes.