Gastrointestinal Blood Loss, Gastroscopy and Coagulation Factors in Normal Volunteers During Administration of Acetylsalicylic Acid and Fluproquazone

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Abstract
The influence of 1 wk treatment of fluproquazone, 300 mg daily, and acetylsalicylic acid (Aspirin, Bayer), 3000 mg daily, on the gastrointestinal tract and coagulation factors was compared in a randomized crossover study, in 12 healthy male volunteers. Gastroscopy revealed 2 acute erosions after fluproquazone in 1 subject; 11 of 12 subjects showed .apprx. 80 erosions, petechiae or diffuse bleedings after aspirin. Median fecal blood loss, as assessed by 51Cr tagging and measurement of bulk radioactivity in a whole-body counter, were significantly (P < 0.01) raised from 1.8 (range 0-6.5) ml during the preceding control wk to 6.0 (range 1.9-10.5) ml after treatment with aspirin. No significant difference was recorded between control and treatment wk with fluproquazone. Mean bleeding time was significantly increased by 40% with aspirin; no statistically significant change was observed with fluproquazone. Prostaglandin synthesis was not significantly influenced by fluproquazone but was almost completely suppressed by aspirin. Coagulation factors II-VII-X decreased slightly but remained within the normal range with both drugs. A markedly smaller effect of fluproquazone was seen compared with aspirin on the gastrointestinal tract and on hemostatic factors.