Induction of Protective Immunity toListeria monocytogenesby Immunization with Plasmid DNA Expressing a Helper T-Cell Epitope That Replaces the Class II-Associated Invariant Chain Peptide of the Invariant Chain
Open Access
- 1 May 2002
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (5) , 2676-2680
- https://doi.org/10.1128/iai.70.5.2676-2680.2002
Abstract
Listeriaepitope-specific helper T (Th) cells were able to be primed and induced in vivo by immunization with a plasmid carrying an invariant chain (Ii) gene whose class II-associated invariant chain peptide (CLIP) region was replaced by aListeriaTh epitope. Immunization of C3H/He mice with an Ii-LLO 215-226 plasmid induced specific interferon-γ- and interleukin 2-producing Th cells and conferred significant protective immunity against listerial infection.Keywords
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