COMPARISON OF INULIN, IOTHALAMATE, AND DTPA-TC-99-M FOR MEASUREMENT OF GLOMERULAR-FILTRATION RATE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 17  (4) , 317-320
Abstract
Clearances of inulin, 125I-iothalamate and 99mTc-Sn-DTPA (diethylenetriaminepertaacetic acid) were measured simultaneously in 5 mongrel dogs exhibiting a wide range of glomerular filtration rates (GFR). Standard constant-infusion inulin clearance was compared to radionuclide clearances after s.c. injection of the emitters mixed with aqueous epinephrine. All 3 substances had virtually identical clearances. The accuracy, accessibility, low cost, low radiation hazard and short half-life of 99mTc-Sn-DTPA make it an excellent substance for measuring GFR. The s.c. technique offers an accuracy comparable to the more difficult constant-infusion method.

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