Experimentelle Untersuchungen zur Frage der Bedeutung intravasaler Fibrinabscheidung für die Entstehung arteriosklerotischer Wandveränderungen

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Abstract
Experiments were carried out in an attempt to induce arteriosclerotic changes in 110 rabbits and 200 rats. Thrombin was infused partly combined with epsilon-aminocaproic acid following the hypothesis of Duguid. The fibrin formed was found to disappear almost completely within hours or days through the action of endogenous fibrinolytic mechanisms. This removal of fibrin was slowed to a certain extent by epsilon-aminocaproic acid treatment. A small part of the remaining fibrin led to changes similar to those seen with emboli, and endothelialisation of layers of fibrin was only observed as a rare exception. The animal experiments so far carried out do not support the hypothesis of transformation of intravasal fibrin precipitates into arteriosclerotic lesions. The additional effect of epsilon-aminocaproic acid on mortality, altered renal function and fibrin formation in lungs and kidneys was analysed.