Conditions required for the bactericidal activity of fleroxacin and pefloxacin against Escherichia coli KL 16
- 1 June 1990
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 32 (2) , 83-86
- https://doi.org/10.1099/00222615-32-2-83
Abstract
Pefloxacin and fleroxacin showed biphasic bactericidal activity against Escherichia coli KL16 in nutrient broth. Bacteriostatic concentrations of chloramphenicol, an inhibitor of protein synthesis, and rifampicin, and inhibitor of RNA synthesis, could not completely abolish the bactericidal activity of either drug. Pefloxafcin and fleroxacin were also active against non-dividing E. coli KL16. Therefore, pefloxacin and fleroxacin are able to kill bacteria which are not dividing nor actively synthesising protein or RNA.This publication has 3 references indexed in Scilit:
- The bactericidal activity of DR-3355, an optically active isomer of ofloxacinJournal of Medical Microbiology, 1989
- 4-Quinolones and the SOS responseJournal of Medical Microbiology, 1989
- Mechanism of Action of Nalidixic Acid on Escherichia coli III. Conditions Required for LethalityJournal of Bacteriology, 1966