Fish Oil Supplementation and Risk of Ventricular Tachycardia and Ventricular Fibrillation in Patients With Implantable Defibrillators
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Open Access
- 15 June 2005
- journal article
- clinical trial
- Published by American Medical Association (AMA) in JAMA
- Vol. 293 (23) , 2884-2891
- https://doi.org/10.1001/jama.293.23.2884
Abstract
Since the original observations that Greenland Eskimos eating a diet high in omega-3 polyunsaturated fats (PUFAs) from sea mammals and fish had an unexpectedly low risk of cardiac death,1,2 multiple lines of evidence have suggested that omega-3 PUFAs have antiarrhythmic properties. Four randomized clinical trials3-6 have shown that dietary changes or supplements to increase omega-3 PUFA intake result in a reduced risk of sudden death without a consistent change in risk of myocardial infarction. To test the hypothesis that omega-3 PUFAs have antiarrhythmic properties, we performed a prospective, double-blind, randomized, placebo-controlled trial of fish oil supplementation in patients with a recent episode of sustained ventricular arrhythmia.Keywords
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