Functionalized 1,2-Dioxetanes as Potentially Useful Biological and Chemotherapeutic Agents
Open Access
- 1 May 1984
- journal article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 39 (5) , 679-682
- https://doi.org/10.1515/znb-1984-0524
Abstract
Hydroxymethyl-substituted 1,2-dioxetanes (3) have been converted in reasonable yields (10-40%) into the carboxylate-substituted 1,2-dioxetanes (4) by means of the Brewster-Ciotti or Mitsunobu esterification and into the tosylate-substituted 1,2-dioxetanes (5) by means of tosyl chloride in pyridine. The fact that hydroxy-functionalized 1,2-dioxetane can be chemically attached to carboxylic acids and sulfonic acids whit preservation of the dioxetane moiety opens up new opportunities for biomedical applicationsKeywords
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