Insulin‐like Growth Factor‐II (IGF‐II) and IGF Binding Proteins in Human Endometriuma
- 1 June 1991
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 626 (1) , 295-307
- https://doi.org/10.1111/j.1749-6632.1991.tb37924.x
Abstract
The insulin-like growth factor autocrine/paracrine system is believed to play a role in steroid-mediated endometrial differentiation. It is constituted of the mitogenic peptides (IGF-I and IGF-II), membrane receptors, and a family of high-affinity binding proteins (IGFBPs) that regulate the actions of the IGFs at their target cells. We have investigated expression of the mRNAs encoding the three major IGFBPs (IGFBP-1, IGFBP-2, and IGFBP-3) in human endometrium and have found, by Northern analysis, differential expression of all three mRNAs in secretory compared to proliferative endometrium, different steroidal milieux. IGF-II mRNAs were also detected in secretory endometrium. Finally, we found that human endometrial stromal cells in culture synthesize and secrete IGFBP-2 and IGFBP-3, and that the synthesis of IGFBP-2 is regulated by steroid hormones.Keywords
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