APOPROTEIN A AND HIGH DENSITY LIPORROTEIN CHOLESTEROL LEVELS IN ISCHEMIC HEART DISEASE

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Abstract
Serum apoprotein A and HDL [high density lipoprotein] cholesterol were determined in 23 patients with ischemic heart disease and in 79 controls. The 23 patients were divided into 2 groups: 14 patients with myocardial infarction and 9 patients with angina pectoris. The mean levels of apoprotein A and HDL cholesterol were significantly lower in the myocardial infarction and angina pectoris groups than in the control group. Although 28 of the 79 controls had low levels of HDL cholesterol, low levels of apoprotein A were seen in 3 control subjects. HDL cholesterol levels were positively correlated with apoprotein A levels in each group. In the 79 controls, 64 subjects involving all females were out of 90% confidence interval of the regression line. Estimating apoprotein A level from HDL cholesterol level was difficult. Multiple regression analysis indicated that HDL cholesterol in the control group was correlated inversely with age, serum triglyceride, VLD[very low density]L, LDL and (VLDL + LDL) cholesterol; apoprotein A in the control group was inversely correlated with serum triglyceride and VLDL but correlated positively with serum cholesterol. There were no specific correlations in the group of ischemic heart disease. The balance of lipids and lipoproteins may be disrupted by metabolic or genetic derangements especially in patients with ischemic heart disease. Each of the HDL components, lipid moiety and apoprotein, should be determined at the same time to characterize the lipid metabolism in atherosclerotic disease. Apoprotein A should be more useful than HDL cholesterol in discriminating between patients with ischemic heart disease and controls.