RECOMBINATION AND COMPLEMENTATION BETWEEN ORTHOMYXOVIRUSES UNDER CONDITIONS OF ABORTIVE INFECTION

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 23  (2) , 97-106
Abstract
On interaction of ts [temperature-sensitive] mutants of fowl plague virus (FPV) belonging to different complementation groups and human influenza A viruses under conditions of abortive infection for both partners, complementation was marked and recombinants occurred with a high frequency. The level and degree of complementation and the frequency of recombinants depended on the stage at which the reproduction of the human influenza A viruses involved was blocked. On simultaneous inoculation of chicks with 2 apathogenic ts mutants of FPV belonging to different complementation groups, pathogenic ts+ recombinants appeared. On interaction of influenza B virus with ts mutants of FPV or UV-irradiated FPV, neither complementation nor recombination was observed. There was no complementation between influenza B virus and ts mutants of FPV even at the level of the formation of virus-specific substructures.